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The present study describes the quantitative retention - (anticancer)   activity relationship analysis of a series of 17-picolyl and   17-picolinylidene androstane derivatives based on the chromatographic data   obtained by reversed-phase high performance liquid chromatography   (C18-RP-HPLC) in a mobile phase consisting of 90% of methanol and 10% of   water. The obtained retention factor or chromatographic lipophilicity factor   (logk0.90) was correlated with the antiproliferative activity of studied   compounds (IC50) toward androgen-receptor negative prostate cancer cell line   (AR-neg. PC-3). Correlation analysis was carried out by applying non-linear   artificial neural networks (ANNs) method. Statistical validation showed that   the obtained ANNs can successfully predict the IC50 values of structurally   similar androstane derivatives

acta periodica technologica/acta periodica technologica

Chromatographic lipophilicity as a predictor of antiproliferative activity of 17-picolyl and 17-picolinylidene androstane derivatives toward prostate cancer