Correlation between the lipophilicity and antifungal activity of some benzoxazole derivatives | Zendy

Sanja Podunavac-Kuzmаnоvić | Zendy; Sonja D. Velimirović | Zendy

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Correlation between the lipophilicity and antifungal activity of some benzoxazole derivatives

Author(s) -

Sanja Podunavac-Kuzmаnоvić,

Sonja D. Velimirović

Publication year - 2010

Publication title -

acta periodica technologica

Language(s) - English

Resource type - Journals

eISSN - 2406-095X

pISSN - 1450-7188

DOI - 10.2298/apt1041177p

Subject(s) - lipophilicity , benzoxazole , quantitative structure–activity relationship , chemistry , antifungal , molecular descriptor , stereochemistry , computational chemistry , organic chemistry , biology , microbiology and biotechnology

In the present work, a quantitative relationship between the lipophilicity and antifungal activity of some benzoxazole derivatives against Candida albicans was investigated by using QSAR (quantitative structure-activity relationship) analyses. The descriptors which describe numerically the lipophilicity, logP, were calculated using Chem-Office Software version 7.0. The linear correlation between the minimal inhibitory concentration (log1/cMIC) and lipophilicity descriptors was investigated. The best QSAR model predicting the antifungal activity of the investigated series of benzoxazole was developed. The results are discussed on the basis of statistical data. High agreement between theoretical and experimental inhibitory values was obtained. The results of this study indicate that the lipophilicity parameter has a significant effect on antifungal activity of this class of compounds, which can be very useful in the design of new biologically active molecules

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