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Background: Alkaline phosphatase is a glycoprotein that catalyzes two kinds  of chemical reactions: hydrolysis of phosphorus ester breaking P-O bonds and  phospho-transfer reactions in which phosphoric group is transferred to an  acceptor molecule. In the human body, ALP exists in multiple molecular forms  whose heterogeneity is partly due to genetic factors and partly to  posttranslational modifications. The aim was to evaluate a total ALP activity  and its isoforms in cancer patients with bone and liver metastasis in  comparison to healthy controls. Methods: Human serum was collected from 20  healthy individuals, and 20 cancer patients with bone and liver metastases,  with metastases confirmed by ultrasound, computerized tomography and a  radiology scan. Determination of ALP was done by the endpoint  spectrophotometric method. Isoenzymes were determined by heat inactivation  method. Results: In cancer patients, the total ALP activity was significantly  higher (p< 0.05) compared to healthy controls. In the sera of cancer patients  with liver metastases, the remaining ALP activity was two-fold higher in  comparison to bone metastases. Conclusion: Determination of ALP isoenzymes is  important but a correct clinical interpretation in the context of other  analyses is vital for a proper diagnosis of a disease. [Projekat Ministarstva  nauke Republike Srbije, br.175056

Values of alkaline phosphathase and their isoenzyme profiles in patients with cancer in respect to bone and liver metastasis