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Background: This is a retrospective study to assess the effectiveness of  consolidation radiotherapy (CRT) following palliative chemotherapy in  patients with metastatic or locally advanced non-small cell lung cancer  (NSCLC) who are not suitable for radical treatment. Methods: This study  involved retrospective analysis of a prospective database of Northampton  Oncology Center from January 2005 through December 2010, 63 patients with  advanced/metastatic NSCLC treated at the oncology center were enrolled.  Patients were either treated with high dose (39/36 Gy /13-12 fractions,  group 1) or low dose (20 Gy /5 fractions, group 2) CRT or there were those  who were not offered any CRT (group 3). Results: There was no significant  difference between the three groups as regard age, sex, performance status,  comorbidities or chemotherapy given. However, there was a statistically  significant difference as regard the stage P = 0.009 with more stage IV  patients at group II and III compared to group I. The mean survival for the  three groups was 27m, 14m & 15m respectively. There was a statistically  significant improvement of survival in patients treated with high dose  palliative CRT compared to the other two groups (P = 0.006). In multivariate  analysis only the radiotherapy dose remains as the only statistical  significant factor affecting the survival with hazard ratio 0.372 and  confidence interval (0.147-0.726). Conclusion: Despite the limitation of our  retrospective study, it is worth considering CRT approach for patients with  advanced and metastatic NSCLC - not suitable for radical treatment - who  have not progressed on chemotherapy

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Palliative chemotherapy followed by consolidation radiotherapy in patients with advanced and metastatic non-small cell lung cancer not suitable for radical treatment