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Background: FS-1 is a complex of iodine and synthesized polysaccharides and  it is very effective against a number of microbe and virus strains. The aim  of the study was to evaluate possible genotoxic properties of FS-1. Methods:  The compound was studied in rat and mouse bone marrow micronucleus (MN) assay  and the comet assay in murine peripheral blood leukocytes, hepatocytes, and  kidney cells. Two treatment protocols were applied, namely acute and subacute  ones. In the first protocol, the compound was administered orally once and in  subacute treatment two times, 24 h apart. The animals were sacrificed 24 h  after the last treatment, and appropriate cells were used to assess DNA  damage and MN induction. Results: In none of the tests (MN and comet assays)  significant increase compared with respective negative controls was observed.  Conclusion: The fact that the compound neither induces DNA damage in various  organs of mice nor is effective in the induction of MN in bone marrow cells  of rats and mice is important for future genotoxicity studies of FS-1, which  can be used in clinical medicine after additional testing of safety for  humans

Investigations of genotoxic activity of the antimicrobial/antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays