Nucleogenesis and origin of organelles | Zendy

Milanko Stupar | Zendy

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Nucleogenesis and origin of organelles

Author(s) -

Milanko Stupar

Publication year - 2008

Publication title -

archive of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.104

H-Index - 13

eISSN - 1450-9520

pISSN - 0354-7310

DOI - 10.2298/aoo0804088s

Subject(s) - genome , biology , mitochondrial dna , gene duplication , compartment (ship) , homologous recombination , organelle , plastid , dna , genetics , nuclear gene , genetic recombination , recombination , gene , evolutionary biology , inner membrane , mitochondrion , oceanography , chloroplast , geology

Division of the ancestral prokaryotic pragenome into two circular double-stranded DNA molecules by genetic recombination is a base for the future separate evolution of the nuclear and mitochondrial gene compartment. This suggests monophyletic origin of both mitochondrion and nucleus. Presumed organism which genome undergoes genetic recombination has to be searched among an aerobic, oxygen non-producing archaeon with no rigid cell wall, but a plasma membrane. Plastids evolve from an aerobic, oxygen producing proto-eukaryot, after mitoplastide genome duplication and subsequent functional segregation. In this proposal, origin of eukaryots occurs by a three-step mechanism. First, replication fork pauses and collapses generating a breakage in the genome of archaeal ancestor of eukaryots. Second, the double-strand break can be repaired intergenomically by complementary strands invasion. Third, this duplicated genome can be fissioned into two compartments by reciprocal genetic recombination. Scenario is accomplished by aberrant fission of the inner membrane surrounding separately those two compartments

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