The action of ionizing irradiation alone or in combination with cisplatin on malignant cells: Investigations in vitro | Zendy

Zorica D. Juranić | Zendy; Slobodanka Čolaković | Zendy; Milan Sarić | Zendy; S. Čikariċ | Zendy

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The action of ionizing irradiation alone or in combination with cisplatin on malignant cells: Investigations in vitro

Author(s) -

Zorica D. Juranić,

Slobodanka Čolaković,

Milan Sarić,

S. Čikariċ

Publication year - 2003

Publication title -

archive of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.104

H-Index - 13

eISSN - 1450-9520

pISSN - 0354-7310

DOI - 10.2298/aoo0303193j

Subject(s) - in vivo , cisplatin , in vitro , cytotoxic t cell , ionizing radiation , cancer research , irradiation , medicine , radiation therapy , tumor cells , pharmacology , chemistry , biology , chemotherapy , biochemistry , microbiology and biotechnology , physics , nuclear physics

The paper gives a brief review of the literature data based on in vitro investigations of cytotoxic action of cisplatin and irradiation, applied alone or in combination, to carcinoma cell lines and fresh tumor explants. Presented data, observed in the light of data obtained in clinics, indicate that in vivo some additional tumor destructive activity might be induced by applied therapy. Therefore examinations of the antitumor effect of some treatment need to be more complex and must include determination of the effects of applied therapy on set of parameters, which control tumor growth in vivo

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