Locally advanced breast cancer as a model for biomarkers research | Zendy

Dragica NikolićVukosavljević | Zendy

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Locally advanced breast cancer as a model for biomarkers research

Author(s) -

Dragica NikolićVukosavljević

Publication year - 2003

Publication title -

archive of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.104

H-Index - 13

eISSN - 1450-9520

pISSN - 0354-7310

DOI - 10.2298/aoo0303135n

Subject(s) - angiogenesis , breast cancer , molecular biomarkers , medicine , cancer research , cancer , apoptosis , biomarker , oncology , in vivo , biology , biochemistry , microbiology and biotechnology

The presence of the tumor in locally advanced breast cancer as an in vivo model offers the possibility of studying the effect of primary anticancer therapy on biological parameters. The hypothesis is that changes in certain molecular biomarkers, particular determinants of tumor growth such as proliferation or apoptosis, or molecular biomarkers of angiogenesis modulation, may predict clinical outcome. In this review, numerous molecular biomarkers of proliferation (ER alpha and ER beta, PR, EGF-R family) and apoptosis (p53, Bcl-2 family), as well as molecular biomarkers of angiogenesis (FGF, VEGF) are discussed for their possible role in locally advanced breast cancer growth

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