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Human adipose-derived stromal/stem cells (hASCs) have been considered a   valuable cell source for generating induced pluripotent stem cells (iPSCs).   Adipose tissue is easy to obtain. Moreover, the isolated cells rapidly   proliferate to reach the required number of cells. Some authors have already   shown that iPSCs can be successfully obtained using adult hASCs.   Nevertheless, little is known about the generation of iPSCs using hASCs   isolated from the tissues of patients over the age of 70. In this study, we   examined the generation of iPSCs from hASCs isolated from a 75-year-old man.   We transduced hASCs with human transcription factors OCT4, SOX2, c-MYC and   KLF4 and observed the formation of human embryonic stem cell (hESC)-like   colonies. The efficiency of the reprogramming process was 0.08% at day 18   post-infection. Reprogrammed cells expressed pluripotent state-specific   transcription factors OCT4, SOX2, NANOG and KLF4, and were able to   differentiate into three germ layers in vitro

Generation of human induced pluripotent stem cells from adipose-derived stromal/stem cells isolated from a 75-year-old patient