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A recently isolated Streptomyces sp. JRG-04 from a mangrove estuary was   identified as a producer of a broad-spectrum antimicrobial compound against   various pathogens, including multidrug resistant (MDR) pathogens, with no   cytotoxic effect on H9C2 cells. In this study, the concentrations of various   nutrient factors and culture conditions were optimized by both classical and   statistical methods for an improved titer of the antimicrobial compound   production. Among nutrient factors, carbon and nitrogen sources such as   maltose and yeast extract stimulated the production of the antimicrobial   compound with the highest titer. The production medium, with a pH 7.5 at   28°C, promoted increased antimicrobial compound production. All   non-statistically optimized nutrients and environmental conditions were used   for subsequent statistical optimization using a Plackett-Burman design (PBD)   and response surface methodology (RSM). Maltose, yeast extract and the   inorganic salt NH4Cl were found to be significant components for   antimicrobial compound production by the PBD method. Interactions between   important variables were evaluated using central composite design (CCD) of   response surface methodology. The final optimized medium (L-1) contained: 10   g maltose, 2.9 g Na2HPO4, 2.3 g KH2PO4, 1 g NH4Cl, 0.5 g MgSO4×7H2O, 0.002 g   FeSO4, 0.5 g CaCO3, 5.25 g yeast extract and trace elements in 5.0 mL salt   solution (0.1 g ZnSO4×7H2O, 0.3 g H3BO3, 0.2 g COCl2×6H2O, 0.03 g MnCl2 4H2O,   0.03 g Na2MO4×2H2O, 0.02 g NiCl2×6H2O, 0.01 g CuCl2×2H2O). The medium   provided an overall 42.8% increase in antibiotic activity when compared to   the unoptimized medium, from 140.57±0.80 to 210.33±0.57 U/mL

Statistical optimization of medium constituents and conditions for improved antimicrobial compound production by marine Streptomyces sp. JRG-04