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The aim of the present study was to examine the morphometric characteristics   of folliclestimulating hormone (FSH) and luteinizing hormone (LH)   immunoreactive cells in the pituitaries of orchidectomized (Orx) and Orx   testosterone- or estradiol-treated rats. Adult male Orx Wistar rats, 2 weeks   post operation, received estradiol dipropionate (E) or testosterone   propionate (T) for 3 weeks. Both controls, sham-operated (So) and Orx rats,   were injected with solvent, in the same regime. Changes in the volume of pars   distalis, the volumes of individual FSH- and LH-labeled cells, their   numerical density and number were determined by unbiased design-based   stereology. The FSH and LH intracellular content was estimated by relative   intensity of fluorescence (RIF). We observed that Orx caused hyperstimulation   of gonadotropic cells. Their volume, volume density, number, numerical   density and intracellular hormone content significantly increased in   comparison to So controls. Compared to Orx controls, T caused a significant   decrease in the volume and volume density of gonadotropic cells and   immunoreactive FSH and LH formations in their cytoplasm. The volume of the   pars distalis, the numerical density and number of gonadotropic cells were   not changed as compared to Orx controls. Estradiol treatment caused a   significant increase in the volume of the pars distalis, decreases in cell   volume, volume and numerical density of gonadotropic cells, and FSH and LH   intracellular content in comparison to Orx controls. The number of   FSH-labeled cells increased. In conclusion, both T and E reversed all of the   examined parameters of gonadotropic cells of Orx rats to the level of So   controls, except in number. [Projekat Ministarstva nauke Republike Srbije,   br. 173009

Sex steroid application reverses changes in rat castration cells: Unbiased stereological analysis