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Despite high morbidity and mortality, no effective options are available for   the treatment of acute lung injury (ALI). Therefore, the present study   investigated the protective effect of honokiol (HK) on ALI via determination   of its effect on several key biomarkers. The results of the study showed that   HK significantly inhibited the infiltration of neutrophils and protein   leakage induced by lipopolysaccharide (LPS) (p<0.05). The pretreatment with   HK considerably boosted the endogenous antioxidant defense system to   counteract the oxidative stress in LPS-induced ALI by elevating the levels of   superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH). Moreover,   the activity of toxic mediators, such as myeloperoxidase (MPO), and lipid   peroxidation were significantly inhibited upon treatment with HK. In order to   examine the mechanism of action of HK, its effect was quantified using matrix   metalloproteinase-9 (MMP-9) activity in bronchoalveolar lavage fluid (BALF)   by gelatin zymography. Pretreatment with HK considerably suppressed the   activation of MMP-9 in a concentration-dependent manner. These findings   suggest that HK protects from lung injury via inhibition of MMP-9, and by   enhancing the activity of the endogenous antioxidant defense system

Protective effect of honokiol against LPS-induced lung injury via attenuation of matrix metalloproteinase-9 and oxidative stress