English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Patients with diabetes mellitus (DM) develop tendencies toward heart disease.   Hyperglycemia induces the release of serotonin from enterochromaffin cells   (EC). Serotonin was observed to elevate reactive oxygen species (ROS) and   downregulate antioxidant enzymes. As a result, elevated levels of serotonin   could contribute to diabetic complications, including cardiac hypertrophy. In   the present study, diabetes mellitus was induced in rats by alloxan   administration; this was followed by the administration of serotonin to   experimental animals. ROS, catalase (CAT), superoxide dismutase (SOD), B-type   natriuretic peptide (BNP) expression, and histopathological assessments were   performed. Elevated ROS concentrations and decreased antioxidant enzyme   activities were detected. Further, we observed an increase in cell surface   area and elevated BNP expression which suggests that events associated with   cardiac hypertrophy were increased in serotonin-administered diabetic rats.   We conclude that serotonin secretion in diabetes could contribute to diabetic   complications, including cardiac hypertrophy, through enhanced ROS   production

Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat