The effects of evodiamine on serum total cholesterol and triglyceride levels are associated with the activation of the AMPK signaling pathway in rats with hyperlipemia | Zendy

Hui Yu | Zendy; Hai Hu | Zendy; Wuzhuang Gong | Zendy; Yang Li | Zendy; Zhanli Wang | Zendy; Cuifeng Wang | Zendy

Open Access

The effects of evodiamine on serum total cholesterol and triglyceride levels are associated with the activation of the AMPK signaling pathway in rats with hyperlipemia

Author(s) -

Hui Yu,

Hai Hu,

Wuzhuang Gong,

Yang Li,

Zhanli Wang,

Cuifeng Wang

Publication year - 2016

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs150904046y

Subject(s) - evodiamine , ampk , triglyceride , medicine , endocrinology , chemistry , cholesterol , pharmacology , protein kinase a , kinase , biochemistry

Evodiamine, a naturally occurring indole alkaloid, has been reported to have numerous biological activities, including antitumor, antimicrobial and anti-inflammatory effects. Previous studies also suggest that evodiamine prevents obesity. In this study, we confirmed that evodiamine lowered the levels of serum total cholesterol (TC) and triglycerides(TG) in rats with hyperlipemia. Furthermore, our findings suggest that the activation of the AMP-activated protein kinase (AMPK) pathway might contribute in part to the effect of evodiamine on the serum levels of TC and TG

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