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The discovery of the post-transcriptional gene silencing (PTGS) mechanism,   widely known as RNAi (RNA interference),has contributed towards the   elucidation of the cellular machinery involved in the response against viral   infections based on gene silencing, and in developmental regulation of   translational suppression. The application of RNAi in insect pest management   (IPM),and gene functional analysis, has been of enormous importance.   Unfortunately, as RNAi has many times proven to be difficult to examine in   Lepidoptera, focus has shifted to other potential post-genomic options in   IPM. Special attention has afforded to novel DNA insecticides based on   preparations of short single-stranded fragments of baculovirus anti-apoptosis   genes, which represent a safe and relatively rapid alternative approach for   IPM. This paper focuses on the draw backs and advantages of DNA insecticides   used in gypsy moth control and based on RNAi

Biological control of gypsy moth (Lymantria dispar): an RNAi-based approach and a case for DNA insecticides