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The aim of the present study was to assess the wound-healing efficiency of   the Prunella vulgaris extract (PVE) on thermally injured rats. Sixty adult,   female rats were divided into four groups, with group I serving as a sham   control (without a burn injury). A burn was inflicted on the dorsum of all   the rats in the second, third and fourth groups. Group II rats served as the   burn-injury control group without any treatment. The burn-injured areas of   the rats in the third and fourth groups were treated topically by 1% silver   sulfadiazine (SSD) cream or 10% PVE-based cream, respectively. Biochemical   (antioxidant, lipid peroxidation, hydroxyproline, mucopolysaccharide),   morphological and histopathological evaluations showed the burn-healing   efficiency of PVE to be better than that of the SSD group. In conclusion,   topical application of PVE enhanced collagen synthesis and antioxidant levels   by suppressing lipid peroxidation as well as increasing proliferation of   keratinocytes, and thus positively influenced wound-healing

The enhanced epithelialization potential of the aqueous extract of Prunella vulgaris in thermally injured rats