English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Ovarian cancer is the leading cause of death from gynecologic cancer,   reflecting its chemoresistance and frequent late diagnosis, and suggesting   that a more effective treatment approach is needed. Lysyl oxidase (LOX) is   involved in important biological processes such as gene regulation, cell   signaling and cell motility, its deregulation contributing to tumor   formation and development. Although it is known that LOX is involved in   proliferation, migration and invasion in several types of tumors, studies of   LOX in ovarian cancers are scarce. To explore the molecular regulation   mechanisms in ovarian cancer tumorigenesis, the expression change   and the function of LOX was confirmed in ovarian tissues and cells, which   suggested that LOX is a tumor suppressor gene. To further understand how LOX   expression is regulated in ovarian cancer, microRNAs(miRNAs) were considered   because of their role in post-transcriptional regulation of many genes.   Recent work has described differential expression of mature miRNAs in human   cancers. Bioinformatics prediction which was used to find the appropriate   miRNA regulating LOX, revealed that miR-29b regulates LOX protein level via   its binding site on the 3'UTR of LOX mRNAin ES-2 cells, a human ovarian   clear cell carcinoma cell line. miR-29b knockdown inhibited proliferation and   invasion in ES-2 cells. Taken together, these findings suggest that   influencing LOX regulation bychanging the level of miR-29b expression could   provide a novel potential approachfor treating human ovarian clear cell   carcinoma

miR-29b regulates cell proliferation and invasion in human ovarian clear cell carcinoma by targeting Lysyl oxidase (LOX)