Potential anticancer activity of curcumin analogs containing sulfone on human cancer cells | Zendy

Qiuyan Zhang | Zendy; Dongli Li | Zendy; Yue Liu | Zendy; Hui Wang | Zendy; Changyuan Zhang | Zendy; Huarong Huang | Zendy; Yan He | Zendy; Xuan Chen | Zendy; Zhiyun Du | Zendy; Xi Zheng | Zendy

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Potential anticancer activity of curcumin analogs containing sulfone on human cancer cells

Author(s) -

Qiuyan Zhang,

Dongli Li,

Yue Liu,

Hui Wang,

Changyuan Zhang,

Huarong Huang,

Yan He,

Xuan Chen,

Zhiyun Du,

Xi Zheng

Publication year - 2015

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs150323134z

Subject(s) - curcumin , stat3 , protein kinase b , cancer cell , apoptosis , prostate cancer , in vivo , cancer research , chemistry , cell culture , mtt assay , cell growth , pi3k/akt/mtor pathway , stat protein , cancer , in vitro , pharmacology , biology , biochemistry , medicine , genetics , microbiology and biotechnology

Three curcumin analogs(S1-S3) containing sulfone were investigated for their effects on human prostate cancer PC-3, colon cancer HT-29, lung cancer H1299 and pancreatic cancer BxPC-3 cells. The three compounds were approximately 16-to 96-fold more active than curcumin in these cell lines as determined by the MTT assay. The effects of these compounds on cell growth were further studied in prostate cancer PC-3 cells in both two dimensional (2D) and three dimensional (3D) cultures. S1-S3strongly inhibited the growth and induced cell death in PC-3 cells, and the effects of these compounds were associated with suppression of nuclear factor kappa B (NF-κB) transcriptional activity. Moreover, treatment of PC-3 cells with all three compounds caused a decrease in the level of phosphorylated signal transducer and activator of transcription-3 (p-STAT3) (Tyr705),but not p-STAT3(Ser727). Only S1and S2decreased the presence of phosphorylated Akt (p-Akt) in PC-3 cells. These curcumin analogs warrant further in vivo studies for anticancer activities in suitable animal models

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