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Central carbon metabolism is the main source of energy required by organisms   and it provides precursors for other in vivo metabolic processes. The flux   flowing through the pathways involved in central carbon metabolism   characterizes its biological function and genetic readout between species or   environments. In recent years, using a 13C tracer technique, researchers have   measured the flux of central carbon metabolism in Corynebacterium glutamicum   under a variety of nutritional and environmental changes or genetic   modifications. However, there is no integrated and comparative analysis of   these measured flux values. In this study, the flux values of central carbon   metabolism in Corynebacterium glutamicum that were obtained in other recent   studies were consolidated. A preliminary examination of the distribution   characteristics of flux values in each metabolic pathway was conducted and   the regression relationship between different fluxes was investigated. The   principal components of the flux vector were further extracted and aggregated   based on the components, and the general features of flux distribution of   central carbon metabolism as well as the influence of environmental and   genetic factors on the flux distribution were determined. This study provides   a foundation for further investigation into the flux distribution and   regulation characteristics of central carbon metabolism

Investigation into the flux distribution of central carbon metabolism in Corynebacterium glutamicum using principal component analysis