Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus | Zendy

Marina Milenković | Zendy; Dragana D. Božić | Zendy; Violeta Slavkovska | Zendy; Branislava Lakušić | Zendy

Open Access

Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus

Author(s) -

Marina Milenković,

Dragana D. Božić,

Violeta Slavkovska,

Branislava Lakušić

Publication year - 2015

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs141119057m

Subject(s) - salvia officinalis , antimicrobial , essential oil , antibiotics , staphylococcus aureus , officinalis , minimum inhibitory concentration , broth microdilution , traditional medicine , sage , microbiology and biotechnology , biology , methicillin resistant staphylococcus aureus , food science , medicine , bacteria , genetics , physics , nuclear physics

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due to the acquisition of resistance to current antimicrobials pose a serious challenge for therapy, and new measures to treat and prevent this infectious pathogen are of crucial importance. Plant essential oils (EOs) and their constituents are promising agents with antimicrobial properties. The aim of this study was to evaluate the antistaphylococcal effect of essential oils from Salvia officinalis using the broth-microdilution method. Essential oils of S. officinalis were isolated from the same individual, but at different life stages - young and old leaves. The effects of combinations of sub-inhibitory concentrations of oil and different antibiotics were evaluated by the checkerboard method. The results, expressed as the fractional inhibitory concentration (FIC) and index (FICI), indicate that the essential oil isolated from young leaves potentiated the inhibitory effect of antibiotics against tested MRSA strains. [Projekat Ministarstva nauke Republike Srbije, br. 173021

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