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Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due   to the acquisition of resistance to current antimicrobials pose a serious   challenge for therapy, and new measures to treat and prevent this infectious   pathogen are of crucial importance. Plant essential oils (EOs) and their   constituents are promising agents with antimicrobial properties. The aim of   this study was to evaluate the antistaphylococcal effect of essential oils   from Salvia officinalis using the broth-microdilution method. Essential oils   of S. officinalis were isolated from the same individual, but at different   life stages - young and old leaves. The effects of combinations of   sub-inhibitory concentrations of oil and different antibiotics were evaluated   by the checkerboard method. The results, expressed as the fractional   inhibitory concentration (FIC) and index (FICI), indicate that the essential   oil isolated from young leaves potentiated the inhibitory effect of   antibiotics against tested MRSA strains. [Projekat Ministarstva nauke   Republike Srbije, br. 173021

Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus