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Hepatitis C virus infection has reached epidemic proportions worldwide and   there is increased interest in its occurrence in children. While there are   certain controversies regarding the mechanisms and management of chronic   viral hepatitis C in children, in the present study we were interested in   comparing, from a biological perspective, the types of responses to two   different management options in chronic viral hepatitis C in children:   monotherapy with pegylated interferon (PEG-IFN) and interferon associated   with ribavirin, for a period of one year. The obtained results showed that in   almost 49% of the patients that received monotherapy treatment a sustained   virological response was present. For the patients that received combined   IFN-ribavirin therapy for one year, the sustained virological response was   present in almost 50% of them. These findings show that the combination of   interferon and ribavirin treatment was effective in children with chronic   hepatitis C, however, further studies are needed to identify the optimum   management of this pediatric population

Biological aspects regarding the management of chronic viral hepatitis C in children