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Angiotensin II receptor antagonists (ARBs) modulate the function of the   renin-angiotensin-aldosterone system and are commonly prescribed   antihypertensive drugs, especially in patients with renal failure. In this   study, the relationship between several molecular properties of seven ARBs   (candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan,   valsartan) and their fecal elimination data obtained from the literature were   investigated. The ARB molecular descriptors were calculated using three   software packages. Simple linear regression analysis showed the best 2   correlation between fecal elimination data and lipophilicity descriptor,   ClogP values (R2 = 0.725). Multiple linear regression was applied to examine   the correlation of ARBs’ fecal elimination data with their lipophilicity and   one additional, calculated descriptor. The best correlation (R2 = 0.909 with   an acceptable probability value, P <0.05) was established between the ARB   fecal elimination data and their lipophilicity and aqueous solubility data.   Applying computed molecular descriptors for evaluating drug elimination is of   great importance in drug research

The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists