The effects of wild-type and mutant SOD1 on smooth muscle contraction | Zendy

Aleksandra NikolićKokić | Zendy; Zorana Oreščanin-Dušić | Zendy; Ivan Spasojević | Zendy; Duško Blagojević | Zendy; Zorica Stević | Zendy; Pavle Andjus | Zendy; Mihajlo Spasić | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The effects of wild-type and mutant SOD1 on smooth muscle contraction

Author(s) -

Aleksandra NikolićKokić,

Zorana Oreščanin-Dušić,

Ivan Spasojević,

Duško Blagojević,

Zorica Stević,

Pavle Andjus,

Mihajlo Spasić

Publication year - 2014

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs141006023n

Subject(s) - sod1 , amyotrophic lateral sclerosis , isometric exercise , superoxide dismutase , chemistry , wild type , genetically modified mouse , mutant , dismutase , medicine , endocrinology , microbiology and biotechnology , enzyme , biology , biochemistry , transgene , gene , disease

In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS. [Projekat Ministarstva nauke Republike Srbije, br. 173014 i br. 175083

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research