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Down syndrome (DS) is characterized by mental retardation and the development   of Alzheimer’s disease (AD). The reason for this development is not yet   clear. Ts65Dn mice were used in this study. We collected their hippocampi and   identified protein biomarkers using isobaric tags for relative and absolute   quantitation (iTRAQ). We described the biochemical characteristics of   proteins and explored their complicated network using GOA, Kyoto Encyclopedia   of Genes and Genomes (KEGG) pathway and network analysis. There were 374   significant differential proteins in the hippocampi of Ts65Dn mice. These   were mainly binding proteins, related to single-organism and cellular   processes. KEGG pathway analysis revealed that the insulin-signaling pathway   was enriched with DS. Using PAJEK, a network of protein interactions was   constructed and the top ten hub proteins were FYN, YBX1, VIM, PRKACA, EWSR1,   H2AFX, CACNA1A, PTN, TFCP2L1 and CRKL. Through preliminarily discovered   differentially expressed proteins by iTRAQ and bioinformatics analysis, we   concluded that these proteins could be closely related to the neurological   deficits of DS

Bioinformatic characterization of differential proteins in the hippocampus of Ts65Dn: A mouse model of down syndrome