The subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain | Zendy

Ivan Simić | Zendy; Violeta Irić-Ćupić | Zendy; Rada Vučić | Zendy; Marina Petrović | Zendy; Violeta Mladenović | Zendy; Mirjana Veselinović | Zendy; Vladimir Ignjatović | Zendy; Jelena Vučković-Filipović | Zendy

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The subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain

Author(s) -

Ivan Simić,

Violeta Irić-Ćupić,

Rada Vučić,

Marina Petrović,

Violeta Mladenović,

Mirjana Veselinović,

Vladimir Ignjatović,

Jelena Vučković-Filipović

Publication year - 2014

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1403075s

Subject(s) - oxidative stress , superoxide dismutase , glutathione , striatum , lipid peroxidation , chemistry , hippocampus , pharmacology , endocrinology , medicine , biochemistry , enzyme , dopamine

The aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain

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