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The finding that estrogen receptor ERβ agonists induce regression of ectopic   endometrial implants in a rodent model has rekindled interest in the role of   ERβ in the growth and maintenance of human endometriosis. We hypothesize that   the ERβ agonist may have a direct effect on the human endometrium. We   examined the mRNA and protein expression of ERβ in both eutopic and ectopic   endometrium and performed a luciferase reporter assay for the presence of   functional ERβ in human endometrial stromal cells. Diarylpropionitrile (DPN -   a ERβ specific agonist) significantly inhibited endometrial stromal cell   proliferation at 10 M by 25% but not at 10 nM. ERβ mRNA is present in both   eutopic and ectopic endometrium; however, protein expression is absent in   both stroma and epithelium. Our search for functional ERβ similarly showed an   absence in endometrial stromal cells. These results suggest that the   regression of endometriosis might be ERβ-independent

Estrogen receptor β agonist inhibits proliferation of endometrial stromal cells in an estrogen-receptor independent manner