Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children | Zendy

Tatjana Damnjanović | Zendy; Ljiljana Luković | Zendy; Dragana Cvetković | Zendy; Biljana Jekić | Zendy; Vera Bunjevački | Zendy; Nela Maksimović | Zendy; Suzana Cvjeticanin | Zendy; Nada MajkićSingh | Zendy; S. Slavko | Zendy; Ivaovaković | Zendy

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Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children

Author(s) -

Tatjana Damnjanović,

Ljiljana Luković,

Dragana Cvetković,

Biljana Jekić,

Vera Bunjevački,

Nela Maksimović,

Suzana Cvjeticanin,

Nada MajkićSingh,

S. Slavko,

Ivaovaković

Publication year - 2014

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1402729d

Subject(s) - methylenetetrahydrofolate reductase , genotype , allele , polymorphism (computer science) , medicine , cholesterol , reductase , lipid profile , low density lipoprotein , lipoprotein , allele frequency , endocrinology , biology , gene , genetics , enzyme , biochemistry

The effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism on serum lipid profiles is controversial. We randomly selected 530 healthy schoolchildren that were included in the Yugoslav Study of the Precursors of Atherosclerosis in School Children (YUSAD). The detected frequencies of MTHFR 677TT genotypes and MTHFR 677T allele were 13.4% and 35.5%, respectively. The mean levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides were higher and high-density lipoprotein cholesterol was lower in the group of children with TT genotype compared with remaining genotypes. All differences were without statistical significance. Our findings suggest that there is no influence of MTHFR C677T gene variants on the lipid parameters in the population of Serbian children. [Projekat Ministarstva nauke Republike Srbije, br. 175091

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