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Cystic fibrosis (CF) is the most frequent autosomal recessive genetic disease   in Caucasians. Although epidemiological studies continue to provide data and   information that could lead to a better understanding of the clinical   manifestations of the disease, there are still many controversies regarding   the importance of some risk factors, such as pain, depression or anxiety in   the pathogenesis of this disorder and its management. In the present study,   we focused on the relevance of these 3 factors in the management of CF and to   their related mechanisms in this disorder. Our original data showed that   pain, depression and anxiety, determined by using a specific quality of life   (KINDL) questionnaire, are important in understanding this disorder, the   effectiveness of treatment and could also represent important factors for   improving treatment. The screening and treatment of these specific   manifestations in CF patients is recommended and holds promise for improving   the outcome of patients with CF

Understanding the relevance of pain, depression and anxiety-like manifestations in the management of cystic fibrosis