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Cholestasis is a multifactorial disorder with various biological, infectious,   toxic, genetic and metabolic manifestations, its principal feature presented   as reduced bile flow or abnormalities in bile formation. It has lately been   accepted that some specific biological markers would shorten the period   needed to establish a positive diagnosis, as currently it is necessary to   navigate through a complex diagnostic protocol for this disorder. The   purpose of this study was to establish some biological parameters and   biomarkers useful for cholestasis management in children. Two hundred   thirty-two children with cholestasis were selected, during a six-year study.   The biological indicators followed were serum bilirubin, gamma-glutamyl   transpeptidase, aspartate transaminase, alkaline phosphatase, lactate   dehydrogenase, serum cholesterol and triglycerides. Our data showed that   certain biological parameters are more often involved in the various forms   of cholestasis, and the conclusions of this study could be useful in the   early detection of cholestasis and appropriate disease management

Some biological indicators relevant for the management of cholestasis in children