Mesenchymal stem cells isolated from human periodontal ligament | Zendy

Maja Miletić | Zendy; Slavko Mojsilović | Zendy; Ivana Okić Djordjević | Zendy; Тамара Кукољ | Zendy; Aleksandra Jauković | Zendy; J.F. Santibaсez | Zendy; Gordana Jovčić | Zendy; Diana Bugarski | Zendy

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Mesenchymal stem cells isolated from human periodontal ligament

Author(s) -

Maja Miletić,

Slavko Mojsilović,

Ivana Okić Djordjević,

Тамара Кукољ,

Aleksandra Jauković,

J.F. Santibaсez,

Gordana Jovčić,

Diana Bugarski

Publication year - 2014

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1401261m

Subject(s) - mesenchymal stem cell , cd90 , stem cell , homeobox protein nanog , microbiology and biotechnology , cd44 , sox2 , cd34 , periodontal fiber , biology , chemistry , immunology , embryonic stem cell , cell , medicine , induced pluripotent stem cell , dentistry , biochemistry , genetics , gene

Mesenchymal stem cells (MSCs) were isolated from human periodontal ligament (hPDL-MSCs) and characterized by their morphology, clonogenic efficiency, proliferation and differentiation capabilities. hPDL-MSCs, derived from normal impacted third molars, possessed all of the properties of MSC, including clonogenic ability, high proliferation rate and multi-lineage (osteogenic, chondrogenic, adipogenic, myogenic) differentiation potential. Moreover, hPDL-MSCs expressed a typical MSC epitope profile, being positive for mesenchymal cell markers (CD44H, CD90, CD105, CD73, CD29, Stro-1, fibronectin, vimentin, α-SMA), and negative for hematopoietic stem cell markers (CD34, CD11b, CD45, Glycophorin-CD235a). Additionally, hPDL-MSCs, as primitive and highly multipotent cells, showed high expression of embryonic markers (Nanog, Sox2, SSEA4). The data obtained provided yet further proof that cells with mesenchymal properties can be obtained from periodontal ligament tissue. Although these cells should be further investigated to determine their clinical significance, hPDL-MSCs are believed to provide a renewable and promising cell source for new therapeutic strategies in the treatment of periodontal defects. [Projekat Ministarstva nauke Republike Srbije, br. 175062 i br. III 41011

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