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The aspect of reticular fibers is not considered in the current   classifications of lung fibrosis. The aim of our study was to evaluate the   distribution and the architecture of the reticular fibers for potential use   as a tissue marker of fibrosis severity. We included in our study 25   pulmonary samples obtained by video-assisted thoracoscopy surgery (VATS) from   a number of 20 cases. The cases were subdivided according to four criteria   into: degree II, III and IV. We noticed no significant changes in the   reticular network from interalveolar septa to the cases scored with 0, an   accumulation of reticular fibers in the interalveolar septa (stage II), the   condensation and thick bundles with network disorganization in all areas   affected by fibrosis (stage III), partial to full depletion of reticular   fibers (stage IV). Depletion of reticular fibers was constantly associated   with advanced fibrosis stages

The reticular network contributes to the staging of idiopathic lung fibrosis