In vitro cytotoxic and teratogenic potential of sediment extracts from Skadar Lake using fish cell line RTL-W1 and Danio rerio embryos | Zendy

A. Perovic | Zendy; Svetlana Perović | Zendy; ThomasBenjamin Seiler | Zendy; Henner Hollert | Zendy

Open Access

In vitro cytotoxic and teratogenic potential of sediment extracts from Skadar Lake using fish cell line RTL-W1 and Danio rerio embryos

Author(s) -

A. Perovic,

Svetlana Perović,

ThomasBenjamin Seiler,

Henner Hollert

Publication year - 2013

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1304539p

Subject(s) - danio , pollutant , sediment , zebrafish , environmental chemistry , bioassay , oryzias , acute toxicity , rainbow trout , contamination , biology , toxicity , environmental science , chemistry , ecology , fish <actinopterygii> , fishery , biochemistry , paleontology , organic chemistry , gene

As a part of Sediment Quality Triad (SQT), organic extracts of sediment from Skadar Lake (a Mediterranean lake and the largest freshwater reservoir in southeastern Europe) were investigated in order to evaluate possible ecotoxicologi- cal contamination by organic pollutants and to obtain a comprehensive insight into the ecotoxicological hazard. Sediments were investigated for toxicity by two different bioassays. Acute cytotoxicity was investigated using the fibroblast-like cell line RTL-W1 (Oncorhynchus mykiss) in combination with the neutral red retention assay. The embryos of zebrafish (Danio rerio) were used to assess the toxic and teratogenic potential of organic extracts of the sediment. Preliminary results point to the presence of a cytotoxic and teratogenic potential in Skadar Lake sediment extracts in certain locations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research