Comparative study of the differentiation potential of rat bone marrow mesenchymal stem cells and rat muscle-derived stem cells | Zendy

Alexandra Ivan | Zendy; Valentin Ordodi | Zendy; Cean Ada | Zendy; Daniela Ilie | Zendy; Carmen Panaitescu | Zendy; Gabriela Tănasie | Zendy

Open Access

Comparative study of the differentiation potential of rat bone marrow mesenchymal stem cells and rat muscle-derived stem cells

Author(s) -

Alexandra Ivan,

Valentin Ordodi,

Cean Ada,

Daniela Ilie,

Carmen Panaitescu,

Gabriela Tănasie

Publication year - 2013

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1304307i

Subject(s) - mesenchymal stem cell , stem cell , bone marrow , stem cell transplantation for articular cartilage repair , population , adult stem cell , pathology , amniotic stem cells , biology , adipogenesis , bone marrow stem cell , microbiology and biotechnology , cellular differentiation , medicine , biochemistry , environmental health , gene

We present a comparative study of the plasticity of rat bone marrow mesenchymal stem cells (MSCs) and rat muscle-derived stem cells (MDSCs). The study was performed on two cell populations that were isolated by aspiration from the femur bone marrow and gastrocnemius muscle biopsy of 6-week-old albino rats. Both cell populations were exposed to identical stimulation conditions. The cells were capable of undergoing osteogenic, chondrogenic, adipogenic and epithelial differentiation, as shown by histochemistry and immunostaining techniques. The MDSC population showed behavior and characteristics similar to the bone marrow MSC population; however, the osteogenic and adipogenic potential was more reduced compared to MSCs. Our results indicate a positive expression of E cadherin and Cytokeratin 10 after 28 days under epithelial stimulation, suggesting a potential use for gastrocnemius muscle MDSCs as a promising source for regenerative therapies, including re-epithelialization and skin regeneration

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