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The aim of this study was to examine whether the thermogenic potential of rat  interscapular brown adipose tissue (IBAT) changes in response to acute and/or  chronic exposure to non-thermal stressors (immobilization and isolation), by  measuring the uncoupling protein 1 (UCP-1) content, MAO-A, SOD and CAT  activities, as well as the number of IBAT sympathetic  noradrenaline-containing nerve fibers. Both acute immobilization (2 h) and  chronic isolation (21 days), as well as their combined effects, significantly  increased the IBAT UCP-1 content in comparison to non-stressed animals. When  applied individually, stressors increased the number of sympathetic fibers in  comparison to controls, whereas in combination they decreased it. The  activity of IBAT monoamine oxidase-A (MAO-A) decreased under the influence of  each stressor independent of its type or duration. SOD activity coincided  with MAO-A decrement, whereas CAT activity had an opposite pattern of  changes. We conclude that acute and chronic exposure to non-thermal  stressors, immobilization and isolation, respectively, affect the metabolic  potential of rat IBAT, judging by the increase in UCP-1 content and  sympathetic outflow. However, when acute immobilization was applied as a  novel stressor to previously chronically isolated animals, an increase in the  UCP-1 content was accompanied by a lower IBAT sympathetic outflow, suggesting  that IBAT metabolic function under various stress condition is not solely  dependent on SNS activity. [Projekat Ministarstva nauke Republike Srbije, br.  173023

Single and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activity