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The aim of this study was to examine the effects of intrastriatally injected  nitric oxide synthase (NOS) inhibitors, Nω-nitro-l-arginine methyl ester  (L-NAME) and 7-nitroindazole (7-NI), on quinolinic acid (QA)-induced toxicity  in selective vulnerable brain regions of adult Wistar rats. QA was  administered into the striatum unilaterally, in a single dose of 150 nM/L  with a stereotaxic instrument. The other two experimental groups were  pretreated with L-NAME and 7-NI, respectively. The control group of animals  was treated with 0.154 mM/L saline solution. The animals were decapitated  seven days after the treatment. Samples of both striatum and forebrain cortex  were prepared for measurement of acetylcholinesterase (AChE) activity. QA  injection revealed a significant increase in AChE activity in both the ipsi-  and contralateral striatum and forebrain cortex compared to the control  animals. Treatment with NOS inhibitors, followed by QA, very clearly  demonstrated lower levels of AChE bilaterally in these brain structures,  compared to the QA-treated group

Nitric oxide synthase inhibitors protect cholinergic neurons against quinolinic acid toxicity in the rat brain