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Prostate cancer (PCa) is the second most commonly diagnosed cancer among men  worldwide. Despite its high incidence rate, the molecular basis of PCa onset  and its progression remains little understood. Genome-wide association  studies (GWAS) have greatly contributed to the identification of single  nucleotide polymorphisms (SNP) associated with PCa risk. Several GWAS  identified 8q24 as one of the most significant PCa-associated regions. The  aim of this study was to evaluate the association of SNP rs378854 at 8q24  with PCa risk in the Serbian population. The study population included 261  individuals diagnosed with PCa, 257 individuals diagnosed with benign  prostatic hyperplasia (BPH) and 106 healthy controls. Data quality analysis  yielded results showing deviations from Hardy-Weinberg equilibrium in groups  of PCa patients and BPH patients as well as in the control group. There was  no significant association between alleles and genotypes of the genetic  variant rs378854 and PCa risk in the Serbian population. [Projekat  Ministarstva nauke Republike Srbije, br. 173016

Assessment of possible association between rs378854 and prostate cancer risk in the Serbian population