English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The function of peroxisome proliferator-activated receptor γ (PPARγ) in  immune regulation, as well as in antiinflammatory and anti-proliferative  actions towards T lymphocytes, has been reported. A potential role of PPARs  in multiple sclerosis (MS) was suggested. The aim of this study was to  investigate if there is an association of PPARγ-2 Pro12Ala polymorphism with  MS in 361 patients from Serbia. The genotype and allele frequencies of  Pro12Ala polymorphism were not significantly different between controls and  patients, or between females and males. In contrast to controls, we detected  a rare Ala/Ala genotype in patients with MS. We found that there is a  significant association of Ala/Ala genotype with older age at onset (ANOVA,  p=0.07; LSD post-hoc, Ala/Ala vs. Pro/Ala, p=0.03, Ala/Ala vs. Pro/Pro  p=0.02). It would be useful to validate our results in other populations, as  well as to perform follow-up of the disease progression in regard to PPARγ  genotypes. [Projekat Ministarstva nauke Republike Srbije, br. 175085

The Ala/Ala genotype of PPARY Pro12 Ala polymorphism is associated with late onset of multiple sclerosis