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In diabetes, pancreatic islets are subjected to high levels of inflammatory  mediators that can lead to beta cell destruction. We recently showed that  pancreatic islet cells derived from MIF-deficient (MIF-KO) mice are resistant  to apoptosis induction by the cytotoxic stimuli of cytokines. Here we show  that MIF-KO islets under cytokine (IFN-γ+TNF- α+IL-1β) stimulation express  and secrete significantly lower amounts of IL-1β, while the expression of  caspase-1 mRNA is not influenced by MIF deficiency. These data suggest that  MIF-KO islets possess an innate defect in the process of IL-1 β synthesis and  secretion

Deficiency of macrophage migration inhibitory factor (MIF) inhibits cytokine-induced IL-1β generation in murine pancreatic islet cells