Deficiency of macrophage migration inhibitory factor (MIF) inhibits cytokine-induced IL-1β generation in murine pancreatic islet cells | Zendy

Ivana Stojanović | Zendy; Tamara Saksida | Zendy; Stanislava StošićGrujičić | Zendy

Open Access

Deficiency of macrophage migration inhibitory factor (MIF) inhibits cytokine-induced IL-1β generation in murine pancreatic islet cells

Author(s) -

Ivana Stojanović,

Tamara Saksida,

Stanislava StošićGrujičić

Publication year - 2013

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1301009s

Subject(s) - macrophage migration inhibitory factor , islet , pancreatic islets , endocrinology , cytokine , medicine , secretion , apoptosis , tumor necrosis factor alpha , cytotoxic t cell , caspase 1 , biology , inflammation , chemistry , diabetes mellitus , in vitro , inflammasome , biochemistry

In diabetes, pancreatic islets are subjected to high levels of inflammatory mediators that can lead to beta cell destruction. We recently showed that pancreatic islet cells derived from MIF-deficient (MIF-KO) mice are resistant to apoptosis induction by the cytotoxic stimuli of cytokines. Here we show that MIF-KO islets under cytokine (IFN-γ+TNF- α+IL-1β) stimulation express and secrete significantly lower amounts of IL-1β, while the expression of caspase-1 mRNA is not influenced by MIF deficiency. These data suggest that MIF-KO islets possess an innate defect in the process of IL-1 β synthesis and secretion

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