Non-specific biological markers as a screening test for diagnostic of extrapulmonary tuberculosis | Zendy

Goran Stevanović | Zendy; M. Pelemiš | Zendy; Svetislav Pelemiš | Zendy; Momčilo Pavlović | Zendy

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Non-specific biological markers as a screening test for diagnostic of extrapulmonary tuberculosis

Author(s) -

Goran Stevanović,

M. Pelemiš,

Svetislav Pelemiš,

Momčilo Pavlović

Publication year - 2012

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1202489s

Subject(s) - adenosine deaminase , extrapulmonary tuberculosis , tuberculosis , medicine , pulmonary tuberculosis , immunology , antibody , gastroenterology , mycobacterium tuberculosis , adenosine , pathology

Serum concentrations of adenosine deaminase were determined in 223 febrile patients. In 62, we discovered extrapulmonary tuberculosis. Serum levels of immunoglobulin G were monitored in 287 febrile patients, and 68 had extra-pulmonary tuberculosis. Serum concentrations of adenosine deaminase were significantly higher in patients with tuberculosis compared to other patients with fever of unknown origin. Serum concentrations declined during antituberculosis therapy. A correlation with the localization of infection was not found. Levels of immunoglobulin G were higher in patients with tuberculosis. Both tests had high sensitivity and specificity and could therefore be used for screening extrapulmonary tuberculosis; however, they can only be interpreted adequately following a full clinical investigation

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