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Andropause, the culminating phase of ageing in males is characterized by the  decline of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis  that is responsible for somatic development. Estrogens on the other hand,  assume a relevant somatic role, as well as the one in the pituitary. They are  particularly interesting because of their therapeutic uses in certain common  ageing-associated diseases. The aim of the present study was to examine the  effects of subcutaneous treatment with estradiol, dipropionate on the  immunohistomorphometric features of GH cells, in an animal model of the  andropause. Sixteen-month-old Wistar rats were divided into sham-operated  (SO), orchidectomized (Orx) and estradiol dipropionate-treated  orchidectomized (Orx+Edp) groups. Estradiol dipropionate (0.625 mg/kg/day)  was administered subcutaneously for three weeks while the SO and Orx groups  received the vehicle alone. GH cells were identified by the  peroxidase-antiperoxidase (PAP) immunohistochemical procedure. In the Orx+Edp  group, GH cell volumes as well as the relative volume densities were  significantly (p<0.05) decreased, by 27.4% and by 61.1%, respectively, in  comparison with the same parameters of SO animals. Compared to the Orx  animals, the cell volumes and relative volume densities of GH cells in  Orx+Edp group were also significantly (p<0.05) decreased, by 23.2% and by  64.1%, respectively. It can be concluded that chronic estradiol dipropionate  application in an animal in the andropause results in the suppression of  immunohistochemical and morphometric parameters of pituitary GH cells

Estradiol and GH cells: Immunohistomorphometric study in an animal model of andropause