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Most of the physiological effects of Ag II are mediated by the angiotensin II  type 1 receptor. Polymorphisms of the AT1R gene can affect the function of  this receptor and subsequent atherogenic activity. In this study we  investigated the correlation between AT1R A1166C polymorphism and coronary  artery calcification (CAC), a marker of the coronary artery burden. Fifty CAD  patients and fifty healthy individuals fulfilled the inclusion and exclusion  criteria entered this study. CAC was determined in the left main coronary  artery (LMCA), left coronary artery (LCA), right coronary artery (RCA) and CX  by CT-angiography and a blood sample was taken at this time. DNA extracted  from whole blood leukocytes was analyzed by the polymerase chain reaction -  restriction fragment-length polymorphism (PCR-RFLP) assay. There were no  significant differences in genotype and allele frequencies between the CAD  and control groups. The mean calcium score was compared in genotypes and  alleles and no significant difference was seen. In addition, the frequency of  genotypes and alleles was not significantly different in the calcium score  groups (low<100, medium= 100-400, high >400). An analysis was performed  separately in males and females and no significant correlation was found.  According to our results, no association was found between AT1R1166C  polymorphism and the incidence of CAD and CAC score in our study population

Evaluation of the association between AT1R1166C polymorphism and the incidence of cad and CAC score in the Iranian population