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The ethanol extract and methanol fraction of Pityrogramma calomelanos (L.)  link were evaluated for antibacterial, antifungal and modulatory activities  against strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus  aureus, Candida albicans, C. krusei and C. tropicalis. The antimicrobial  activity of the natural products was evaluated by the microdilution method  associated or not with aminoglycosides and antifungals. The ethanol extract  and methanol fraction of P. calomelanos showed good activity against S.  aureus when associated with aminoglycosides and with benzoilmetronidazol  against species of the genus Candida. These results indicate that P.  calomelanos should be studied as a possible source of natural products to  combat bacteria and fungi either directly or by modulating the mechanisms of  resistance of these microorganisms, enhancing the antimicrobial activity of  these drugs and combating microbial resistance

Enhancement of antimicrobial activity of antibiotics and antifungals by the use of natural products from Pityrogramma calomelanos (L.) link