Immunohistochemical evidence for the presence of a vasoactive intestinal peptide, neuropeptide Y and substance P in rat adrenal medulla after heat stress | Zendy

Dragana Petrović-Kosanović | Zendy; Vesna Koko | Zendy

Open Access

Immunohistochemical evidence for the presence of a vasoactive intestinal peptide, neuropeptide Y and substance P in rat adrenal medulla after heat stress

Author(s) -

Dragana Petrović-Kosanović,

Vesna Koko

Publication year - 2012

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1201007p

Subject(s) - vasoactive intestinal peptide , adrenal medulla , neuropeptide y receptor , substance p , medicine , endocrinology , ganglion , neuropeptide , immunohistochemistry , medulla , biology , catecholamine , chemistry , anatomy , receptor

Immunohistochemistry revealed the presence of VIP-, NPY- and SP-immunoreactivity in the rat adrenal medulla. VIP- and NPY-immunoreactivity was detected in chromaffin and ganglion cells and in nerve fibers, but SP-immunoreactivity was found only in chromaffin cells. After acute heat stress, VIP- and NPY- immunoreactivities in cells and nerve fibers were reduced, probably as a result of the release of these peptides with catecholamines. The absence of SP-immunoreactive ganglion cells in the adrenal medulla suggests that the SP-immunoreactive nerve fibers are extrinsic in origin

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