Mesenchymal stem cell properties of dental pulp cells from deciduous teeth | Zendy

Nataša Marković | Zendy; Jelena Krstić | Zendy; Drenka Trivanović | Zendy; Slavko Mojsilović | Zendy; Jelena Kocić | Zendy; Juan F. Santibáñez | Zendy; G Jovčić | Zendy; Diana Bugarski | Zendy

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Mesenchymal stem cell properties of dental pulp cells from deciduous teeth

Author(s) -

Nataša Marković,

Jelena Krstić,

Drenka Trivanović,

Slavko Mojsilović,

Jelena Kocić,

Juan F. Santibáñez,

G Jovčić,

Diana Bugarski

Publication year - 2011

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1104933n

Subject(s) - mesenchymal stem cell , cd90 , deciduous teeth , dental pulp stem cells , cd34 , stem cell , cd44 , microbiology and biotechnology , immunophenotyping , stem cell marker , biology , vimentin , cell , immunology , medicine , flow cytometry , immunohistochemistry , dentistry , biochemistry

In the present study we have isolated and identified mesenchymal stem cells (MSCs) from the exfoliated deciduous teeth dental pulp (DP-MSCs), as plastic-adherent, spindle-shaped cells with a high proliferative potential. Immunophenotype analyses revealed that DP-MSCs were positive for mesenchymal cell markers (CD90, CD44, CD105, STRO-1, vimentin and α-SMA), and negative for hematopoietic stem cell markers (CD11b, CD33, CD34, CD45, CD235a). DPMSCs were also capable of differentiating into adipogenic, chondrogenic, myogenic and osteogenic lineages, fulfilling the functional criterion for their characterization. These results demonstrate that DP-MSCs offer a valuable, readily accessible source to obtain and store adult stem cells for future use

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