Chromosome instability in Alzheimer’s disease | Zendy

Biljana SpremoPotparević | Zendy; Lada Živković | Zendy; Bosiljka PlećašSolarović | Zendy; Vladan Bajić | Zendy

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Chromosome instability in Alzheimer’s disease

Author(s) -

Biljana SpremoPotparević,

Lada Živković,

Bosiljka PlećašSolarović,

Vladan Bajić

Publication year - 2011

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1103603p

Subject(s) - chromosome instability , telomere , disease , dementia , chromosome , biology , centromere , genome instability , alzheimer's disease , genetics , medicine , neuroscience , pathology , dna , gene , dna damage

Alzheimer’s disease (AD), as the most common form of dementia, has for many years attracted the attention of researchers around the world, primarily because of the problems of reliable diagnostic methods that could help in the early detection of this devastating disease. One of the important aspects of genetic research related to AD is the analysis of chromosome instability which includes: aneuploidies of different chromosomes, telomere shortening and the phenomenon of premature centromere division (PCD). The aim of this study was to describe specific biomarkers in different types of cells as potential parameters for the diagnosis of AD in order to promptly recognize pre-symptomatic stages and prevent the development of disease and/or slow down its progression

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