Vasopressin modulates hypothalamo-pituitary activity by paracrine action during acute and chronic immobilization stress in rats | Zendy

Iva Lakić | Zendy; Predrag Vujović | Zendy; Nebojša Jasnić | Zendy; Siniša Djurašević | Zendy; Gordana Cvijić | Zendy

Open Access

Vasopressin modulates hypothalamo-pituitary activity by paracrine action during acute and chronic immobilization stress in rats

Author(s) -

Iva Lakić,

Predrag Vujović,

Nebojša Jasnić,

Siniša Djurašević,

Gordana Cvijić

Publication year - 2011

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1103579l

Subject(s) - vasopressin , hypothalamus , medicine , endocrinology , paracrine signalling , receptor , hormone , neuropeptide , corticotropin releasing hormone , chemistry , vasopressin receptor , pituitary gland , antagonist

The aim of the study was to examine changes in corticotropin releasing hormone (CRH), vasopressin (VP), adrenocorticotropin (ACTH) as well as VP3 receptor protein concentration in the hypothalamus and the pituitary of rats exposed to acute (3 h) and chronically repeated (3 h daily for 7 days) immobilization stress. Our results show that, unlike the increase in ACTH, there were no changes in serum VP despite the significant changes in this hormone and its receptor concentrations in the hypothalamus and pituitary (HP). This suggests that VP regulates HP activity by predominantly acting in a paracrine manner under the examined stress condition

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research