Open AccessThe protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart
Author(s) -
S.F. Nabavi,
Seyed Mohammad Nabavi,
Mohammad Ali Ebrahimzadeh,
Shahram Eslami,
Narjes Jafari,
Akbar Hajizadeh Moghaddam
Publication year - 2011
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs1103563n
Subject(s) - curcumin , sodium fluoride , oxidative stress , chemistry , lipid peroxidation , superoxide dismutase , antioxidant , pharmacology , vitamin c , vitamin e , fluoride , polyphenol , toxicity , sodium , biochemistry , medicine , inorganic chemistry , organic chemistry
In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was used as a normal group; groups II and III were pretreated with curcumin intraperitoneally for 7 days prior to NaF intoxication. Group IV was pretreated with vitamin C, a standard antioxidant, intraperitoneally for 7 days prior to NaF intoxication and used as a positive control group. The animals in group V were intoxicated with NaF for the same time and used as a control group. There was a significant increase in lipid peroxidation along with a decrease in superoxide dismutase activity in the homogenates of tissues of the NaF-treated animals. Curcumin pretreatment in animals prior to fluoride intoxication normalized the levels of biochemical parameters measured
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