Open AccessMembers of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression
Author(s) -
Isidora Petrović,
Nataša KovačevićGrujičić,
Jelena Popović,
Aleksandar Krstić,
Milena Milivojević,
Milena Stevanović
Publication year - 2011
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs1103517p
Subject(s) - junb , ap 1 transcription factor , activating transcription factor , creb , atf3 , transcription factor , biology , promoter , angiogenesis , genetics , transcription (linguistics) , gene , gene expression , microbiology and biotechnology , cancer research , linguistics , philosophy
The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene
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