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The SOX18 transcription factor plays an important role in endothelial cell  specification, angiogenesis and atherogenesis. By profiling transcription  factor interactions (TranSignal TM TF Protein Array) we identified several  transcription factors implicated in angiogenesis that have the ability to  bind to the SOX18 optimal promoter region in vitro. In this report we  focused our attention on distinct transcription factors identified by the  array as belonging to AP-1 and CREB/ATF protein families. In particular, we  analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression.  Functional analysis revealed that CREB acts as a repressor, while JunB,  c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings  indicate that a transcriptional network that includes CREB, JunB, c-Jun and  ATF3 could be involved in angiogenesis-related transcriptional regulation of  the SOX18 gene

Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression