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The nature and extent of estrogen and progesterone action on the lacrimal  gland is not known, and neither are the targets for their action.  Immunohistochemical detection of estrogen and progesterone receptors in the  human lacrimal glands in both sexes in different age groups was performed in  this study. Twenty human lacrimal glands from autopsies were analyzed by the  immunohistochemical method of cell counting and the χІ test. Estrogen and  progesterone receptors were detected in the lacrimal glands of both sexes  with significantly higher total and average cell counts in females (p<0,001).  Estrogen and progesterone receptors are present in human lacrimal glands with  age and gender dependent expression