Renoprotective effect of Eryngium caucasicum in Gentamicin-induced nephrotoxic mice | Zendy

Shahram Eslami | Zendy; Mohammad Ali Ebrahimzadeh | Zendy; Akbar Hajizadeh Moghaddam | Zendy; S.F. Nabavi | Zendy; Nahid Jafari | Zendy; S.M. Nabavi | Zendy

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Renoprotective effect of Eryngium caucasicum in Gentamicin-induced nephrotoxic mice

Author(s) -

Shahram Eslami,

Mohammad Ali Ebrahimzadeh,

Akbar Hajizadeh Moghaddam,

S.F. Nabavi,

Nahid Jafari,

S.M. Nabavi

Publication year - 2011

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1101157e

Subject(s) - gentamicin , nephrotoxicity , chemistry , blood urea nitrogen , creatinine , pharmacology , hydrogen peroxide , urea , intraperitoneal injection , antioxidant , toxicity , biochemistry , antibiotics , medicine , organic chemistry

Recent studies show that hydrogen peroxide free radicals have an important role in the renal damage induced by Gentamicin. Previously we studied the hydrogen peroxide scavenging activity of Eryngium caucasicum. This work was conducted to evaluate the possible renoprotective effect of Eryngium caucasicum against Gentamicin-induced renotoxicity. Extracts at the doses 200 and 400 mg/kg/day for 10 consecutive days, by intraperitoneal route (i.p.) offered renoprotective action by change in the blood urea nitrogen (BUN), serum urea and creatinine. Results show that an extract at 400 mg/kg/ day shows better activity than other tested samples. In conclusion, the extracts showed significant renoprotective activity compared with the control group

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